Dear reader, We would like to announce a new special issue on intelligent systems and applications. Please check at http://www.ijimai.org Editor's Note: The International Journal of Interactive Multimedia and Artificial Intelligence provides an interdisciplinary forum in which scientists and professionals can share their research results and report new advances on Artificial Intelligence and Interactive Multimedia techniques. This special issue includes six extended versions of selected papers from CISTI 2012 - 7th Iberian Conference on Information Systems and Technologies, held in Madrid, Spain, June 20 - 23, 2012 - and one paper from a regular submission to the journal. The issue includes, thus, seven selected papers, describing innovative research work, on several areas of Artificial Intelligence and Interactive Multimedia including, among others: optimization, soft computing, machine learning, web mining, semantic web, ontology networks, object relational databases, multimedia content management, emotion recognition and intelligent agents. We would like to thank all the contributing authors, as well as the members of the conference coordinating, organizing and scientific committees for their hard and valuable work that assured the high scientific standard of the conference and enabled us to edit this special issue. Finally, the Guest Editors would also like to thank the Editors-in-Chief of International Journal of Interactive Multimedia and Artificial Intelligence for the publication of this special issue. Editorial Team IJIMAI